Painful blisters or fluid-filled lesions on the skin should not be ignored or treated without proper evaluation. These symptoms can have various causes, including herpes virus infections, making appropriate medical consultation and testing important.

For suspected Herpes Simplex Virus (HSV) infection, molecular testing such as PCR/NAAT using a sample taken from an active lesion is a sensitive method for detecting HSV and differentiating between HSV-1 and HSV-2. Viral culture may also be performed, although its sensitivity is lower, particularly as lesions begin to heal. Type-specific serologic testing may be useful in selected situations, while HSV IgM testing is not recommended for determining a recent infection.

Unlike herpes simplex, herpes zoster (shingles) results from reactivation of the Varicella-Zoster Virus (VZV), the same virus that causes chickenpox.

Herpes zoster can also be prevented through vaccination. For adults aged 50 years and older, the recombinant zoster vaccine is given as a two-dose series, generally 2–6 months apart. Vaccination is still recommended for people who have previously experienced shingles.

If you experience blisters, pain, or other symptoms suggestive of herpes, consult a doctor to determine the appropriate examination and treatment.