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ROME EXAMINATION (CA 125 and HE 4) FOR OVARIAL CANCER
Thu, 25 Aug 2022
In addition to clinical examination and imaging (USG / MRI), there are laboratory tests that can be performed to diagnose ovarian cancer, namely ROMA examination (CA 125 and HE 4).
CA 125 is a protein found on the surface of ovarian cancer cells and certain healthy tissues. However, higher levels of CA 125 are not always a definite sign of ovarian cancer. Other conditions such as endometriosis and appendicitis can also cause an increase in the CA 125 protein.
HE 4 is an epididymal protein 4 in humans which is a tumor marker that is more sensitive and specific for ovarian malignancies, including early-stage ovarian cancer.
ROMA (Risk of Ovarian Malignancy Algorithm) is a combination of CA 125 and HE 4 examination which provides increased longitudinal sensitivity and improves diagnostic accuracy for ovarian malignancy so that it can be treated properly.
ROMA can be helpful in assessing whether a premenopausal woman with an ovarian adnexal mass has a high or low probability of finding malignancy at surgery.
This examination is carried out by taking the patient's blood and the patient does not require special preparation to perform this ROMA examination.
Author: dr. Puppy Nawangwulan (PRAMITA Clinical Laboratory Medical Consultant Doctor Jl. Jemur Andayani No. 67, Surabaya)
CA 125 is a protein found on the surface of ovarian cancer cells and certain healthy tissues. However, higher levels of CA 125 are not always a definite sign of ovarian cancer. Other conditions such as endometriosis and appendicitis can also cause an increase in the CA 125 protein.
HE 4 is an epididymal protein 4 in humans which is a tumor marker that is more sensitive and specific for ovarian malignancies, including early-stage ovarian cancer.
ROMA (Risk of Ovarian Malignancy Algorithm) is a combination of CA 125 and HE 4 examination which provides increased longitudinal sensitivity and improves diagnostic accuracy for ovarian malignancy so that it can be treated properly.
ROMA can be helpful in assessing whether a premenopausal woman with an ovarian adnexal mass has a high or low probability of finding malignancy at surgery.
This examination is carried out by taking the patient's blood and the patient does not require special preparation to perform this ROMA examination.
Author: dr. Puppy Nawangwulan (PRAMITA Clinical Laboratory Medical Consultant Doctor Jl. Jemur Andayani No. 67, Surabaya)
