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EARLY DETECTION OF HEART DISEASE with HIGH SENSITIVE (HS) TROPONIN I EXAMINATION
Thu, 29 Sep 2022
Coronary Heart Disease (CHD) is a narrowing of blood vessels due to the formation of atherosclerotic plaques which results in impaired oxygen supply to the heart. This blockage of coronary arteries is known as Acute Coronary Syndrome (ACS).
Atherosclerotic formation can progress at varying rates, ranging from luminal narrowing that can progress to sudden total blockage. Sudden total blockage can result from rupture of a non-stenotic plaque that forms a thrombosis, and ultimately causes a decrease in the oxygen-carrying blood supply to the heart.
Acute coronary syndrome (ACS) includes unstable angina and acute myocardial infarction (AMI). Differentiating chest pain from ACS from other causes is a challenge. The diagnosis of AMI is based on at least 2 of the symptoms of ischemia, namely changes in electrocardiography (ECG) and elevated serum cardiac markers.
Early detection examinations should be carried out by those who have risk factors for coronary heart disease.
The most common risk factors include: - men aged 45 years and women 55 years
- hypertensive patients
- hyperlipidemia
- diabetes
- obesity
- smokers and can also be for patients who are asymptomatic though.
High-sensitive Troponin is a highly sensitive and specific biomarker of myocardial necrosis and has been used to diagnose acute myocardial infarction. Cardiac troponins (cTnT and cTnI) are the preferred diagnostic markers, because they can detect microinfarcts, remain elevated up to 2 weeks after symptom onset and are useful as markers of long-standing AMI and are useful in determining risk stratification of ACS. Increased troponin levels are associated with an increased risk of death and the occurrence of AMI.
At this time, Tropononin I Assay is available in the form of high sensitivity, so it can measure Troponin I levels at low levels so that it can be used to detect the presence of myocardial infarction even though the person appears to be healthy.
Author: Prof.Dr.dr. Ellyza Nasrul Sp.PK(K) (Doctor in Charge of PRAMITA Clinical Laboratory Jl. Ahmad Yani No. 39, Padang)
Atherosclerotic formation can progress at varying rates, ranging from luminal narrowing that can progress to sudden total blockage. Sudden total blockage can result from rupture of a non-stenotic plaque that forms a thrombosis, and ultimately causes a decrease in the oxygen-carrying blood supply to the heart.
Acute coronary syndrome (ACS) includes unstable angina and acute myocardial infarction (AMI). Differentiating chest pain from ACS from other causes is a challenge. The diagnosis of AMI is based on at least 2 of the symptoms of ischemia, namely changes in electrocardiography (ECG) and elevated serum cardiac markers.
Early detection examinations should be carried out by those who have risk factors for coronary heart disease.
The most common risk factors include: - men aged 45 years and women 55 years
- hypertensive patients
- hyperlipidemia
- diabetes
- obesity
- smokers and can also be for patients who are asymptomatic though.
High-sensitive Troponin is a highly sensitive and specific biomarker of myocardial necrosis and has been used to diagnose acute myocardial infarction. Cardiac troponins (cTnT and cTnI) are the preferred diagnostic markers, because they can detect microinfarcts, remain elevated up to 2 weeks after symptom onset and are useful as markers of long-standing AMI and are useful in determining risk stratification of ACS. Increased troponin levels are associated with an increased risk of death and the occurrence of AMI.
At this time, Tropononin I Assay is available in the form of high sensitivity, so it can measure Troponin I levels at low levels so that it can be used to detect the presence of myocardial infarction even though the person appears to be healthy.
Author: Prof.Dr.dr. Ellyza Nasrul Sp.PK(K) (Doctor in Charge of PRAMITA Clinical Laboratory Jl. Ahmad Yani No. 39, Padang)
